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Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial

When iron metabolism is disordered or ATG expression is abnormal, iron autophagy mediated by NCOA4 can induce ferroptosis by degrading ferritin and inducing iron overload ( Hypoxia can also affect iron metabolism