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Insulin stimulates GLUT4 translocation to the cell surface, which promotes glucose uptake by the cells and increases insulin sensitivity 30 , which is also controlled by GLUT4 translocation to the membrane 31

Other GLS inhibitors, such as IACS-6274 in head and neck squamous cell carcinoma (HNSCC) and IPN60090 in non-small cell lung cancer (NSCLC) and ovarian cancer, have demonstrated efficacy in preclinical models (160) (161)

Limited data is available on durability of functional cure and/or HBsAg loss