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A study on spinal cord injury demonstrated that the introduction of lactate significantly augments lactylation levels in microglia, effectively inhibiting the expression of pro-inflammatory mediators such as IL-1, iNOS, and TNF- [57]

GSH is a necessary cofactor for GPX4 (glutathione peroxidase 4), a selenoprotein that contains a catalytic site for selenocysteine to exert its antioxidant function in eliminating lipid peroxides (Figure 2A)