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Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor [3] [4]

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In contrast, icariside II targets various cancer types, including bladder cancer (BIU-87 and T24), cervical cancer (Hela), lung cancer (A549 and Lewis), prostate cancer (DU 145), colon cancer (SW620), and melanoma (A2058 and A375R) cells resistant to BRAF inhibitors, by blocking cell cycles, inducing autophagy and apoptosis, and modulating the tumor microenvironment when combined with anti-PD-1 [756,757,758, 762,763,764,765,766]