![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Identification, optimization, and structural elucidation](https://ars.els-cdn.com/content/image/1-s2.0-S0223523421002087-ga1.jpg)
interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Identification, optimization, and structural elucidation
Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C terminal Hydrolase L3 bioRxiv Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S Transferase Pi 1 Inhibition by the Anti cancer Compound Piperlongumine* Journal of Biological Chemistry Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry
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![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Identification, optimization, and structural elucidation](https://www.biorxiv.org/content/biorxiv/early/2026/05/29/2026.05.26.727856/F11.large.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Identification, optimization, and structural elucidation](https://www.jbc.org/cms/10.1074/jbc.M116.750299/asset/9d8dd1e8-8f69-4758-829c-2602b200a4cf/main.assets/gr4_lrg.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Identification, optimization, and structural elucidation](https://ars.els-cdn.com/content/image/1-s2.0-S0223523425008724-ga1.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Identification, optimization, and structural elucidation](https://pubs.acs.org/cms/10.1021/acs.jmedchem.3c00737/asset/images/medium/jm3c00737_0012.gif)