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91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways

61 The intracerebroventricular (ICV) administration of STZ elicits a distinct influence on the central nervous system (CNS) without noticeable effects on peripheral regions

doi: 10.1016/j.cell.2004.07.013 145 HofsethLJSinghUPSinghNPNagarkattiMNagarkattiPS

NACET penetrates mitochondrial membranes to restore redox balance, protecting the electron transport chain from ROS damage