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J.Neurosci, 34, 1530615318

doi: 10.1016/j.jfutfo.2022.08.006 56

Oxidative stress and mitochondrial reactive oxygen species The mitochondrial ETC is the major source of intracellular ROS production [72], and mitochondrial dysfunction can lead to increased levels of superoxides, hydrogen peroxide, and hydroxyl radicals [73]