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This chapter seeks to address these issues and give pathologists a framework with which to handle these challenging specimens

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Product Specifications Product Name : PT141 Chemical Name : Bremelanotide Sequence : Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH Molecular Formula : C50H68N14O10 Molecular Weight : 1025.2 g/mol Form : Lyophilized powder Purity : 98% (HPLC) Volume : Customizabletypically supplied in 10 mg vials Intended Use : Laboratory research only

Although the term PEM allows one to deal with diagnostically challenging pigmented melanocytic tumors, for which a reliable distinction between melanoma and an unusual pigmented nevus is difficult or impossible by light microscopic examination alone, we caution against labeling lesions as PEM, which previously would have been diagnosed as benign EBN or pigmented dermal spindle and epithelioid cell nevus