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In addition to interfering with inflammatory pathways, scoparone has been shown to provide protection from oxidative stress, as demonstrated in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and lipid peroxidation assays in vitro (151, 153), and to inhibit production of ROS and preserve antioxidant enzyme activity in response to several types of oxidative stressors (154, 155)

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A total of 40 participants were selected and randomized into two sequences in a double-blind, placebo-controlled crossover design, with a one-week washout period between treatments to eliminate carryover effects