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Gene essential analysis and in silico drug prediction In silico essential drug prediction was performed on all models using a modified version of the singleGeneDeletion function from the COBRA toolbox [28] and the biomass and ATP production as an objective function for cancer and control models, respectively

Groups who are at higher risk of developing a B12 deficiency include the following: Vegetarians Vegans Pregnant women Breastfeeding women Older women Those who have had gastric bypass surgery or another surgery in which part of the stomach was removed Those who drink alcohol excessively Those taking and of the drugs listed previously such as Metformin How Much B12 Is Enough