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doi: 10.1002/cbdv.202200872 468 WuWXiangFHeF

For instance, combining GSH-targeted delivery with chemotherapy, radiotherapy, or immunotherapy can produce synergistic anticancer effects

Iron metabolism defines macrophage subsets, with M1 macrophages increasing iron retention to exhibit an iron-sequestering phenotype by upregulating ferritin and hepcidin and downregulating TfR1, FPN, and HO-1 expression, compared to M2 macrophages, which exhibit reduced iron levels (termed the iron-releasing phenotype) [68,69,70]