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The normalized ChIP reads in gene bodies relative to all aligned reads are shown for the middle and bottom tercile in terms of gene expression (as determined by RNA-seq RPKM levels across all condition) are shown (lower)

BioMed Res Int 2015:515042

Consequently, in disease states marked by intrinsic energy insufficiency, such as neurodegeneration [42] , it may be the failure of metabolic resilience, rather than the presence of excess free iron, which acts as the primary driver of ferroptosis