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In 1948, Linus Pauling first proposed that enzymes employ transition state stabilization.[72] The concept of ground state destabilization, on the other hand, has only recently been embraced

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demonstrated that FABP inhibitors, BMS3094013 and SBFI-26, represent an effective strategy to target MM progression, both in vitro and in vivo, impacting on oncogenic c-Myc signaling pathway [89]