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The effects of phytoestrogens on breast cancer may be also caused by their ability to inhibit local estrogen synthesis, induce epigenetic changes, and suppression of ER signaling pathways [68, 69]

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A further increase in enzyme activity was not observed by increasing the concentration of the substrate

Certain aromatic amino acid residues of the loop between the 3-helix and 2-sheet of the first monomer play a role as the key