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Under these conditions, mitochondria permeabilize, and proapoptotic factors, such as cytochrome c (Cyt C ) and the apoptosis-inducing factor (AIF), are released into the cytosol

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In preclinical ALD models, the dual chemokine receptor CCR2/CCR5 antagonist cenicriviroc has shown promise in preventing macrophage infiltration and protecting the liver from inflammatory damage [255]