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Urinary riboflavin excretion levels in casual or 24h urine specimens reflect dietary intake but vary widely because concentrations are affected by many non-nutritional factors

GFP is usually not folding correctly in the periplasm, hence the general secretory pathway (Sec) is unsuitable for targeting roGFP2 to the periplasm (Santini et al., 2001)

Moreover, it is employed in the preservation of protein-dithiols by the protein disulfide reductase (glutathione) (EC 1.8.4.2), an enzyme that catalyzes the chemical reaction: This enzyme acts on different substrates, such as insulin, which is inactivated by cleavage of the disulfide bridge, or on protein disulfide, in which the reduction to protein-dithiol restores the catalytic activity, protecting the cell from oxidant stress

doi: 10.1080/08820139.2018.1486411 144 SiW.ZhaoX.LiR.LiY.MaC.ZhaoX.et al