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Hence, to restore the cellular redox state and enable proliferation in the absence of GOT1 and GOT2, aspartate needs to yield asparagine, making asparagine a causative agent in this scenario, and excluding an indirect effect of reduced intracellular availability of aspartate

They may act to induce general anesthesia, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site