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Key administration details for compounded tirzepatide: Subcutaneous injection, once weekly Rotate injection sites: abdomen, thigh, upper arm Store reconstituted solution in refrigerator Refrigeration is required after reconstitution Shelf life in fridge : typically 28-30 days after reconstitution Room temperature stability is limited, see tirzepatide room temperature guidelines Retatrutide administration Retatrutide is currently available only as a research compound in lyophilized powder form

Materials and methods Ethical approval This study, which the Ethics Committee approved with the decision of the Suleyman Demirel University Animal Experiments Local Ethics Committee dated 26.01.2023 and numbered 01/115, was carried out in the laboratories of the Suleyman Demirel University Experimental Animals and Medical Research Application and Research Center

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Hernandez et al., 2022)