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10.1111/j.1365-2036.2010.04522.x 85

This interacts with the HPA axis your body's central stress-response system in a straightforward way: when you're physically exhausted and neurologically compromised, cortisol stays elevated longer, recovery from stressful events takes more time, and the subjective experience of stress intensifies

Research indicates that cells respond to stiffness gradients through a process called durotaxis (from Latin durus meaning hard and Greek taxis meaning arrangement), initially observed using fibroblasts [82]