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c-di-GMP and other bacterial cyclic dinucleotides (CDNs) stimulate the mammalian innate immune response by binding to the stimulator of interferon genes (STING) receptor, thereby converging with the cyclic GMPAMP synthase (cGAS)cyclic GMPAMP (cGAMP) cytosolic DNA-surveillance pathway

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These results validate the gene expression differences associated with regional emphysema severity in independent cohorts from different clinical settings and support the hypothesis that the genes whose expression is associated with regional emphysema severity reflect the activity of true disease-associated processes