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The next paragraphs will discuss genetic predisposition and susceptibility as an underlying risk factor for ME/CFS - the superimposition of external stressors and exposures (59) results in a state of aberrant homeostasis, where a temporary homeostatic state of functioning occurs, but functions at a less optimum level (64)

instead, it may reflect an early adaptive inflammatory phase within a broader reparative trajectory 50

In situations where eliminating the triggering factors is not possible, the key objective is to prevent the dark patches from worsening and further progression

To achieve successful neuronal transplantation, proper integration of the graft in the host circuitry is necessary