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Even in patients with alcohol-associated cirrhosis or severe alcohol-associated hepatitis, there was an approximate 90% reduction in Kupffer cells, as evidenced by downregulation of Kupffer cell signature markers (MARCO, CD5L, and TIMD4) and concurrent upregulation of MoMF-associated genes (TREM2, GPNMB, and SPP1) expression [88]

Indeed, it is known that thanks to KD patients with T2DM can reduce and stabilise glucose levels (fasting, after meals and throughout the day), lower HbA1c and insulin levels, reduce body weight, and reduce (or even wean off) diabetes medication, often achieving full remission