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269 These findings illustrate that PERK signaling exerts dose-, duration-, and context-dependent effects, complicating efforts to therapeutically manipulate this pathway

Here, we elucidate how cellular senescence increases susceptibility to ferroptosis, how ferroptosis contributes to AD progression, and how exercise mitigates these deleterious processes through multilevel regulation of iron metabolism, lipid peroxidation, and antioxidant defense

Depending on the downstream application, affinity purification might be the only chromatographic step required to achieve adequate purity

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