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It is thought that rosmarinic acid, an aromatic phenolic compound found in these and other mint-family plants, may contribute to neuroprotection through its ability to cross the blood-brain barrier and exert anti-inflammatory and free radical-scavenging effects

Depending on the patient, a healthcare professional may consider: Pulse wave velocity is not a blood test, but it can provide physiologic information about arterial stiffness

Data availability The data supporting the findings reported herein are available upon request, from the corresponding author [Satoshi Nagaoka (email: [email protected])]

After removal of the overlying meninges and blood vessels, spinal cords were cut into small pieces, dissociated with 0.05% collagenase I (Thermo Fisher Scientific, Foster City, CA, USA) for 15 min at 37 C, and then processed to produce epSPC neurospheres as previously described 6,18