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Observations in atherosclerotic Apoe-/- mice revealed an inverse correlation between intravesicular miR-92a levels in blood serum and KLF4 expression in lesions, suggesting a potential role for extracellular miR-92a in the formation of atherosclerotic lesions [132]

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Although such data may be confounded by indirect effects of amino-acid substitutions on the structure of the hormone, overall aspects of the long-sought structure of the hormone-receptor complex have been inferred from photo-cross-linking studies and recently been confirmed in a low-resolution co-crystal structure of insulin bound to a fragment of the receptor ectodomain

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