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Another network that integrates amino acid availability with cell physiology is the integrated stress response (ISR) 13,14,15

10.1155/JBB/2006/82323 J

As the mice in that study were kept in a standard animal holding facility (not specific pathogen free), perhaps exposure to infectious agents may have contributed to this early, peripheral deposition of A (which likely would be much more pronounced in an Alzheimers disease model than in wild-type mice)