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Interestingly, while either H 2 O 2 or the organic peroxide tert-butyl-hydroperoxide (t-BOOH) dramatically enhanced p38 phosphorylation levels in wild-type animals, such an effect was largely diminished in sek-1 mutants (Fig

Non-significant differences in GST and lipid peroxide levels were observed between the three studied groups, whereas vitamin C and GSH levels were higher in diabetic patients when compared to those in controls

In summary, age-dependent changes such as increased catalytic iron levels, weakened antioxidant defenses, elevated mitochondrial-derived oxidative stress and sustained membrane vulnerability to peroxidation, collectively place neurons in the aging brain in a fragile state

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