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To identify these regulators, we conducted immunoprecipitation-coupled mass spectrometry (IP-MS) and identified an alternative ORF (alt-ORF) C11ORF98 -encoded microprotein (herein named RSMC, 28S rRNA/ribosome and Sororin micro-cofactor) as a Sororin partner in human cells

Miyaoka T, Yasukawa R, Yasuda H, Hayashida M, Inagaki T, Horiguchi J

Following the indicated treatment, 10 M DCFH2-DA was added to the cell culture medium and incubated for 25 min

In neurons, TRPM2 contributes to calcium-mediated excitotoxicity and cell death, while, in microglia, it promotes overactivation, proinflammatory cytokine production, and sustained neuroinflammation