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Finally, retinoic acid (RA), the primary vitamin A metabolite, cooperates with catalase to induce monocyte differentiation into macrophages, and it can remove H 2 O 2 effectively [60]

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This large size can impede diffusion within the dense tumor extracellular matrix, frequently restricting accumulation to perivascular regions and preventing penetration into hypoxic, acidic tumor cores, a limitation that contributes to heterogeneous therapeutic responses [221]

Kristy Prouse , medical doctor trained in functional medicine with a background in genetics and cell biology