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Therapeutic redistribution of metal ions to treat alzheimers disease

They encapsulated Mn 2+ -siPD-L1 nanoprecipitate cores within a hyaluronic acid (HA) shell (AHA@MnP/siRNA)

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Second, in both cell models RSL3 induced upregulation of canonical, albeit not entirely specific, ferroptosis markers at a transcriptional level, including glutathione-specific -glutamylcyclotransferase 1 ( Chac1 ), prostaglandin-endoperoxide synthase 2 ( Ptgs2 ) and the system x c antiporter ( Slc7a11) (Fig