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Impaired function of the MPC is frequently observed in specific CRC subtypes, driving a metabolic shift toward glycolysis, enhancing stemness, and conferring resistance to OXPHOS inhibitors [52, 53]

doi: 10.3389/fmicb.2018.02050 Received 26 January 2018 Accepted 13 August 2018 Published 31 August 2018 Volume 9 - 2018 Edited by Rosalba Lanciotti, Universit degli Studi di Bologna, Italy Reviewed by Panagiotis Skandamis, Agricultural University of Athens, Greece

reported three patients with non-surgical, Crohns-related ileal malabsorption and bile acid diarrhea with marked reduction of fecal bile acid output, and improvement in their stool frequency and consistency during 23 weeks of treatment with ED [42]

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