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However, HLA-DR4 antibodies failed to show any correlation with the viral load

doi:10.1016/S1474-4422(14)70052-3

it may also be formed as a result of (a) semicarbazide-sensitive amine oxidase-mediated oxidative deamination of the methylamine derived from creatinine (Charlton and Mack, 2008) and (b) chromatin structure remodeling in the reaction of methyl groups removal from lysine residues in histones, which is catalyzed by lysine-specific demethylase 1 and JmjC domain-containing histone demethylases (Tsukada et al., 2006