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Synthetic antioxidants provide targeted support, while natural oxidants, derived from plant sources, contribute to a holistic and sustainable therapeutic strategy since they are used within regulations parameters (197)

Studies indicate that genes linked to PMN-MDSCs are enriched in the ferroptosis pathway, suggesting their susceptibility to ferroptosis (Zhang et al., 2020)

This step leads to activation of these compounds to their reactive electrophilic metabolites with potential mutagenic and cancerogenic effect

The relatively low AUC of 0.64 for patient/carrier comparisons likely reflects overlap in age distribution, with many carriers already within the disease onset window, Supplemental Information Fig