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152 Experimental findings have suggested that the oxidation of Met residues by cigarette smoke or free radicals released from inflammatory cells not only reduces the anti-elastase activity of AAT but also converts AAT into a proinflammatory molecule

In the first study, blinded evaluators used urodynamic and voiding parameters to rate patient improvement ("objective criteria") and patients rated global improvement ("subjective criteria")

Moreover, its analogues, idebenone with better bioavailability and efficacy, was shown to attenuate murine lupus (196)

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