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As CoPP structurally mimics heme but cannot be efficiently degraded by HO-1, CoPP treatment has been proposed as a potential therapeutic strategy for oxidative stress-related diseases, including cardiovascular disease 65,66 , diabetes 67 , obesity 68 , septic insults 65 , and metabolic syndrome 69

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Using a U-40 syringe when your dosing instructions assume a U-100 syringe would deliver 2.5 times the intended dose

For this analysis, the datasets for the three timepoints (1, 6, and 20 months) were processed independently and were not integrated prior to UMAP visualization