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Further studies in large population-based cohorts are needed to confirm[59,60]

Consequently, the targeting of SLC1A5-AS/MZF1 in combination with ASCT2 inhibitor therapy may represent a viable strategy for the treatment of HCC

In some cases, the affinity optimization is aimed at increasing the affinity by at least 2-fold, at least 3-fold, at least 4-fold, at least 5-fold, at least 6-fold, at least 7-fold, at least 8-fold, at least 9-fold, at least 10-fold, at least 20-fold, at least 30-fold, at least 40-fold, at least 50-fold, at least 100-fold, at least 500-fold, or at least 1,000-fold or more as compared to the affinity of the original antibody

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