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Thus, some of the oral symptoms in our patients may be related to neuropathic changes of the trigeminal nerve

GSH reduction is associated with TDP-43 inclusion formation in sALS patients (Valle and Carr, 2017) and WT forms of TDP-43 and SOD1 can be induced to misfold and aggregate in neuronal cells (Iguchi et al., 2012

Additionally, IL-6 and IL-23 can drive Th 17 differentiation, with IL-17 recruiting neutrophils that infiltrate thyroid tissue, causing direct damage to follicular epithelial cells (Stadhouders et al., 2018)

Foster M, Samman S (2012) Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease