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(4) Treat obesity partly like a consumer market: direct-to-patient, cash channels, partnerships (telehealth/retail), and meet patients where they are. (5) Oral GLP-1 is positioned as market expansion (not just cannibalization): needle aversion + cold-chain friction are cited as key adoption drivers

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This aggressive first-pass effect leaves very little intact NAC to circulate systemically to the brain or peripheral muscles

Conclusions These findings demonstrate that celastrol alleviates DKD-associated renal injury by inhibiting ferroptosis via activation of the SIRT1/NRF2/GPX4 signalling pathway