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However, UPR can also activate downstream apoptotic signaling pathways and promote apoptosis when the damage is persistent and severe or when the extent of the crosstalk network exceeds the resolution capacity of ER loading aberrations ( Figure 2 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Liang B., Xing D.M

Specifically, three urinary metabolites, p -hydroxy-5,6-dehydro-7,8-dihydrokavain and two dihydroxy-5,6-dehydro-7,8-dihydrokavains, were identified from the metabolism of 7,8-dihydroxyyangonin