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This orexigenic drive appears to be largely GH-independent, as it is observed even in models of GH-deficiency, and is accompanied by rises in leptin that likely reflect expansion of adipose depots and provide a feedback brake on further hyperphagia

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

Figure 2 2.1 Coronary heart disease and atherosclerosis Coronary heart disease (CHD) is a condition in which the arteries cannot supply adequate oxygenated blood to the heart