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These compounds are known to play a role in glutathione production, which helps combat oxidative stress and supports metabolic processes [1][2]

The evidence presented above notwithstanding, the 2020 guidelines for the prevention of CIPN issued by the American Society of Clinical Oncology do not yet endorse GM1 for prevention or treatment of CIPN, citing insufficient evidence (Loprinzi, Lacchetti 2020)

Moreover, gut microbiota-derived metabolites, including D-amino acids and reactive oxygen species, contribute directly to glomerular and tubular dysfunction by promoting oxidative stress and insulin resistance (Nagase et al., 2022)

PMID: 34850093 NeuroreportKnockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a