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SALL2 activity could be restored using DNA methyltransferase (DNMT), therefore co-administration of tamoxifen and DNMT inhibitors like 5-Aza-20-deoxycytidine (5-Aza-dC), is a rational approach to re-sensitize patients tamoxifen resistant breast cancer patients [58]

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Because first year height velocity data suggests that the impact of rhIGF-1 among SPIGFD patients is less pronounced than rhGH for GH-deficiency (rhIGF-1: 6.9 [6.5, 7.2] cm/year [n = 144] vs rhGH: 8.67 [7.5, 9.9] cm/year [n = 465]) [14, 60], some HCPs may not perceive rhIGF-1 as beneficial enough for SPIGFD