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Alkynes and azides have taken a leading role in click chemistry, as they are common functional groups with a mild and chemoselective reactivity profile 7,8,9

Nature 338 , 594596 (1989)

The formation of HSPs in ME/CFS individuals is reduced (302), and the responses of plasma HSP27 and HSP70 are delayed or lowered, while resting levels of plasma HSP70 are also decreased (303)