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Zamudio F, Loon AR, Smeltzer S, Benyamine K, Navalpur Shanmugam NK, Stewart NJF, et al

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

These observations suggest that stimuli damaging to the organism can directly initiate nuclear modifications by epigenetically determined mechanisms

After excluding 2 participants with missing data for essential laboratory tests for GFR estimates, 1 participant who discontinued dabigatran for more than 3 days before drug level measurement, 2 participants in the rivaroxaban group who had no AF diagnosis, and 4 participants in the apixaban group who were on stable hemodialysis, 511 participants were included in the data analysis