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The lateral hemisphere, especially Crus I, receives input from the DLPFC and parietal cortices, providing a substrate for integrating attention, salience, and pain expectation (50, 58)

Non-invasive brain stimulation techniques including the non-convulsive TMS and tDCS and convulsive ECT and MST provide safe options targeting specific areas in dorsolateral prefrontal cortex (DLPFC) which is a key site for the frontoparietal network (FPN)

One reason is that cortisone in high doses (and a typical injection by the doctor is considered a high dose) can weaken joint cartilage and tendons

In summary, LA is a key regulatory molecule in metabolic-inflammatory homeostasis, and its function is highly dependent on the concentration and metabolic microenvironment