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No comprehensive, long-term human safety studies have been published

The FDA's 2026 advisory committee review treats each form as a distinct evaluation target

The main tissue affected during disease progression and readily accessible from joint replacement surgeries, 258 reported increased expression of MMP3, MMP9, MMP13, and ADAMTS4 in femoral head cartilage, correlating with demethylation at specific CpG sites in their promoters