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In addition to affecting canonical receptor signaling, 5-HT also exerts receptor-independent effects via transglutaminase 2 (TGM2)-catalyzed serotonylation, a covalent post-translational modification that modulates substrate protein function 17,18

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For instance, dietary glutamine reduced levels of pro-inflammatory cytokines (including IL-1 and IL-8) while increasing levels of anti-inflammatory/regulatory cytokines (including IL-10) in the small intestine of healthy weaning piglets (123, 124, 166)