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Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y

In addition to the direct suppression of TYR catalytic activity, other methods for the disruption of melanogenesis include the post-transcriptional control of TYR, regulation of melanosome transfer and the suppression TYR transcription by suppressing upstream signaling pathways

Nat Rev Immunol (2017) 17(4):26275

Erythropoiesis: Model systems, molecular regulators, and developmental programs