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Starting with the growing consensus that the overconsumption of readily available and highly palatable foods likely contributes to the growing rates of obesity worldwide (Johnson and Wardle, 2014), the high intake of ultra-processed foods was associated with an increased risk of NAFLD, as evidenced in 6,545 participants who were recruited in National Health and Nutrition Examination Surveys 20112018 (Liu et al., 2022), but the point is that both preference and consumption of sweet substances often parallel the self-administration of several drugs of abuse, and under certain conditions, the termination of intermittent access to sweet substances produces symptoms that resemble those observed during opiate withdrawal (Gosnell and Levine, 2009)