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3.3 Imbalance in mitochondrial fission/fusion dynamics Mitochondria maintain structural and functional homeostasis through dynamic fission and fusion, a process tightly regulated by GTPases ( 2 - generation ( 4 Oxidative stress: a bridge between mitochondria and IR 4.1 Sources and molecular targets of ROS This section integrates how mitochondrial ROS participate in stress kinase signaling, mitochondrial DNA signaling, and the antioxidant network, based on the mechanics of the ETC and the TCA cycle, and links these molecular events to tissue-level insulin action

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